86347-15-1 Medetomidine HCl AKSci G352
 
 
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  G352    AKSci Reference Standard
Medetomidine HCl
, 98% (HPLC)
 
Medetomidine hydrochloride




IDENTITY
CAS Number:86347-15-1
MDL Number:MFCD06798319
MF:C13H17ClN2
MW:236.74
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:Off-white powder
Melting Point:164-169°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:Soluble to 100 mM in Water
Form:HCl salt

REVIEW

 Medetomidine hydrochloride is an alpha-two adrenergic agonist used as both a surgical anesthetic and analgesic in small animal practice (dogs). The drug was developed by Orion Pharma and is currently approved for dogs in the United States, and distributed in the United States by Pfizer Animal Health and by Novartis Animal Health in Canada under the product name Domitor. Medetomidine hydrochloride is a racemic mixture, with one of the enantiomers, dexmedetomidine has been shown to have more useful effects, and is now marketed as Dexdomitor. Interestingly, the free base form of medetomidine (distributed by the Swedish company I-Tech AB, under the product name Selektope) is use as an antifouling substance in marine paints.

REFERENCES
[1]Karjalainen, Arto Johannes; Pohjala, Esko Kalervo; Kurkela, Kauko Oiva Antero Substituted imidazole derivatives and their use Brit. UK Pat. Appl. (1983), GB 2101114 A 19830112.
[2] Turpeinen, Urho; Ruotsalainen, Heikki; Pehkonen, Riitta; Lajunen, Lauri H. J.; Karjalainen, Arto Crystal structure, thermal behavior, protonation and mass spectroscopic studies of racemic 4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole hydrochlorides. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1988), B42(8), 537-45.
[3] Kudzma, Linas V.; Turnbull, Stanhope P., Jr. Expedient synthesis of 4(5)-[1-(2,3-dimethylphenyl)-1H-imidazole, the alpha2-adrenergic agonist medetomidine Synthesis (1991), (11), 1021-22.
[4] Cullen LK. Medetomidine sedation in dogs and cats: a review of its pharmacology, antagonism and dose. Br Vet J. 1996 Sep;152(5):519-35.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 15, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Adrenergic Agonists, Anaesthetics, Veterinary


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