81732-46-9 Bambuterol HCl AKSci G311
 
 
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  G311    
Bambuterol HCl
, 98% (HPLC)
 
Bambec, Oxeol




IDENTITY
CAS Number:81732-46-9
MDL Number:MFCD03427293
MF:C18H30ClN3O5
MW:403.9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:221-232°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: soluble -33mg/mL
Application(s):beta-adrenoceptor agonist
Form:HCl salt

REVIEW

 Inhibits plasma cholinesterase during metabolism. Bambuterol is a racemic phenylethanolamine based long acting beta-adrenoceptor agonist, used in the treatment of asthma; it also is a biscarbamate ester prodrug of the beta 2 adrenergic agonist terbutaline.

REFERENCES
[1]Olsson, Otto Agne; Svensson, Leif Ake; Wetterlin, Kjell Ingvar Leopold 1-(Dihydroxyphenyl)-2-aminoethanol derivatives, their compositions and intermediates Eur. Pat. Appl. (1982), EP 43807 A2 19820113.
[2] Svensson LA.Bambuterol- a prodrug-prodrug with built-in hydrolysis brake. Acta Pharm Suec. 1987;24(6):333-41.
[3] Svensson LA.Mechanism of action of bambuterol: a beta-agonist prodrug with sustained lung affinity. Agents Actions Suppl. 1991;34:71-8.
[4] Sitar DS.Clinical pharmacokinetics of bambuterol.Clin Pharmacokinet. 1996 Oct;31(4):246-56.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 2, 2022


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CATEGORIES

 APIs and Bioactives > Beta Blockers


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