195435-23-5 Triphenyl valsartan AKSci F458
 
 
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  F458    AKSci Bulk Reagent
Triphenyl valsartan
, 98% (HPLC)
 



IDENTITY
CAS Number:195435-23-5
MDL Number:MFCD08460102
MF:C43H43N5O3
MW:677.83
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:155-161°C
Density:1.2
Refractive Index:1.62
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Triphenyl valsartan is an advanced intermediate towards the preparation of valsartan, an angiotension II receptor antagonist, used in the treatment of hypertension.

REFERENCES
[1]Buhlmayer, Peter. Preparation of N-aryl amino acid carboxyalkyl ester derivatives as angiotensin II antagonists PCT Int. Appl. (1997), WO 9730036 A1 19970821.
[2] Cordi, Alexis; Haberkorn, Laure; Verbeuren, Tony; Courchay, Christine; Simonet, Serge; New diazenium diolate derivatives, their preparation process, and the pharmaceutical compositions which contain them. Fr. Demande (2007), FR 2902428 A1 20071221.
[3] Preparation of (S)-N-(1-carboxy-2-methyl-prop-1-YL)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]amine IP.com Journal (2009), 9(5B), 47.
[4] Dallatomasina, Franco; Guandalini, Luca; Martini, Elisabetta; Romanelli, Maria Novella; Method for deprotecting N-protected tetrazole derivatives Ital. Appl. (2006), IT 2006TO0380 A1 20060825.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 1, 2022


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CATEGORIES

 APIs and Bioactives > Angiotensin Receptor Blockers


PubChem
  @PubMed