144690-92-6 Trityl olmesartan medoxomil AKSci F351
 
 
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  F351    
Trityl olmesartan medoxomil, 98% (HPLC)
 
Trityl olmesartan
1H-Imidazole-5-carboxylic acid
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
more..
IDENTITY
CAS Number:144690-92-6
MDL Number:MFCD09954745
MF:C48H44N6O6
MW:800.9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form (at 20°C):White or almost white powder
Melting Point:108-114°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Trityl olmesartan medoxomil is a key intermediate used in the preparation of olmesartan medoxomil, an angiotension II receptor antagonist, used in the treatment of hypertension.

REFERENCES
[1]Yanagisawa, Hiroaki; Shimoji, Yasuo; Fujimoto, Koichi; Kanazaki, Takuro; Anemiya, Yoshiya; Koike, Hiroyuki; Sada, Toshio, Prepeparation of 1-[(carboxy-biphenylyl)methyl]imidazole-5-carboxylates and analogs as angiotensin II antagonists. Eur. Pat. Appl. (1992), EP 503785 A1 19920916.
[2] Zhang, Fuli; Wu, Taizhi Preparation of olmesartan medoxomil. PCT Int. Appl. (2004), WO 2004085428 A1 20041007.
[3] Hedvati, Lilach; Pilarsky, Gideon; Process for the preparation of olmesartan medoxomil. PCT Int. Appl. (2006), WO 2006029056 A1 20060316.
[4] Ramanjaneyulu, Gorantla Seeta; Mohan, Bandari; Ray, Purna Chandra; Sethi, Madhuresh Kumar; Rawat, Vijendra Singh; Krishna, Yerramalla Raja; Lakshminarayana, Vemula; Srinivas, Mamidi; Process for the preparation of olmesartan medoxomil. PCT Int. Appl. (2007), WO 2007148344 A2 20071227.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 19, 2022


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CATEGORIES
 APIs and Bioactives > Angiotensin Receptor Blockers


PubChem