141505-33-1 Levosimendan AKSci F336
 
 
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  F336    AKSci Reference Standard
Levosimendan
, 98% (HPLC)
 
2-[2-[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-propanedinitrile
OR 1259
Simdax




IDENTITY
CAS Number:141505-33-1
MDL Number:MFCD00867135
MF:C14H12N6O
MW:280.28
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:219-224°C
Optical Rotation:-500° - 650° (c=0.5, THF)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >=20mg/mL; H2O
Application(s):Anti-Arrhythmia Agent; Cardiotonic Agent; Phosphodiesterase Inhibitor; Vasodilator Agent
Form:Free Base

REVIEW

 Levosimendan is a calcium sensitiser. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts its positive inotropic effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner. It also has a vasodilatory effect, by opening adenosine triphosphate (ATP)-sensitive potassium channels in vascular smooth muscle to cause smooth muscle relaxation. The combined inotropic and vasodilatory actions result in an increased force of contraction, decreased preload and decreased afterload.

REFERENCES
[1]Plaschke K, Bent F, Rosenhagen C, Wagner S, Hofer S, Kopitz J (2012). The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor. Coron Artery Dis. 23(3):215-20. PMID 22343797.
[2] Memis D, Inal MT, Sut N (2012). The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock. J Crit Care. 27(3):318.e1-6. PMID 21855289.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501


Current as of December 26, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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