REVIEW Tropinone is an alkaloid which shares the same core structure as cocaine, obtained from coca leaves. Tropinone's core structural motif has been actively used in drug discovery to study cocaine's mode of action; as a novel structural motif and building block for synthetic and medicinal chemistry.
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Holloway GA, Parisot JP, Novello PM, Watson KG, Armstrong T, Thompson RC, Street IP, Baell JB.Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.Bioorg Med Chem Lett. 2010 Mar 15;20(6):1816-8.
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