REVIEW A xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor.
REFERENCES
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Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD (2010). Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. J Med Chem. 53(3):1098-108. PMID 20070106.
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Dorfmueller HC, van Aalten DM (2010). Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds. FEBS Lett. 584(4):694-700. PMID 20026047.
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