REVIEW Lentinan is an anti-tumor polysaccharide isolated from the fruit body of the shiitake mushroom Lentinula edodes. It manifests marked antitumor and antimetastatic activity in numerous tumor/host systems, and prevents chemical and viral carcinogenesis. Modulation of immune or vascular functions is involved in its antitumor effects. Limited clinical studies of cancer patients have associated lentinan with a higher survival rate, higher quality of life, and lower re-occurrence of cancer.
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Chihara G; Hamuro J; Maeda Y Y; Shiio T; Suga T; Takasuka N; Sasaki T Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc (1987), 1, 423-43.
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Lien EJ.Fungal metabolites and Chinese herbal medicine as immunostimulants. Prog Drug Res. 1990;34:395-420.
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Kaneko Y, Chihara G.Potentiation of host resistance against microbial infections by lentinan and its related polysaccharides. Adv Exp Med Biol. 1992;319:201-15.
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Chihara G Recent progress in immunopharmacology and therapeutic effects of polysaccharides. Developments in biological standardization (1992), 77, 191-7.
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