[320-67-2] 5-Azacytidine AKSci E730
 
 
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  E730    
5-Azacytidine
, 98% (HPLC)
 
4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
5-Azacitidine
Ladakamycin




IDENTITY
CAS Number:[320-67-2]
MDL Number:MFCD00006539
MF:C8H12N4O5
MW:244.2
EINECS:206-280-2
BRN:620461
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White to off-white powder
Melting Point:207-224°C
Optical Rotation:+36° - +42° (c=1, H2O)
Long-Term Storage:Store long-term at -20°C
UN #:Not hazmat

BIOLOGICAL INFO
Application(s):Inhibits DNA methyltransferase

REVIEW

 5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.

REFERENCES
[1]Siva P. Kumpatla.; Timothy C. Hall. Longevity of 5-azacytidine-mediated gene expression and re-establishment of silencing in transgenic rice. Plant Molecular Biology. 1998, 38, (6), 1113-1122.
[2] Sunil Rangappa.; Chen Fen.; Eng Hin Lee.; Ariff Bongso.; Eugene Sim Kwang Wei. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. The Annals of Thoracic Surgery. 2003, 75, (3), 775-779.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H302; H350

Precautionary Statements
P201; P202; P264; P270; P281; P301+P312; P308+P313; P330; P405; P501


Current as of November 21, 2017


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CATEGORIES

 APIs and Bioactives > Chemotherapeutics
 Nucleobases > Nucleosides


PubChem