317-34-0 Aminophylline AKSci E719
 
 
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  E719    AKSci Bulk Reagent
Aminophylline, 98% (HPLC)
 
3,7-Dihydro-1,3-dimethylpurine-2,6-dione, complex with 1,2-ethanediamine (2:1)
Truphylline
Somopphyllin
more..
IDENTITY
CAS Number:317-34-0
MDL Number:MFCD00013221
MF:C16H24N10O4
MW:420.43
EINECS:206-264-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:269-276°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 53mg/mL; H2O: 50mg/mL; EtOH: <1mg/mL
Application(s):Phosphodiesterase Inhibitor; Purinergic P1 Receptor Antagonist
Form:Ethylenediamine

REVIEW
 Theophylline is structurally related to theobromine and caffeine. The precise mechanism of action of theophylline is not known, however, it is thought to be a phosphodiesterase inhibitor which may give a bronchodilatory effect. It also binds adenosine receptors

REFERENCES
[1]Essayan DM. (2001). Cyclic nucleotide phosphodiesterases.. J Allergy Clin Immunol. 108 (5): 671-80. doi:10.1067/mai.2001.119555. PMID 11692087.
[2] Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R. (2008). Insights into the Regulation of TNF-a Production in Human Mononuclear Cells: The Effects of Non-Specific Phosphodiesterase Inhibition. Clinics (Sao Paulo). 63 (3): 321-8. doi:10.1590/S1807-59322008000300006. PMC 2664230. PMID 18568240.
[3] Marques LJ, Zheng L, Poulakis N, Guzman J, Costabel U (February 1999). Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am. J. Respir. Crit. Care Med. 159 (2): 508-11. PMID 9927365.
[4] Peters-Golden M, Canetti C, Mancuso P, Coffey MJ. (2005). Leukotrienes: underappreciated mediators of innate immune responses. J Immunol. 174 (2): 589-94. PMID 15634873.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of November 21, 2024


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CATEGORIES
 APIs and Bioactives > Asthma


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