REVIEW Estramustine is a chemotherapy agent used to treat prostate cancer. It primarily functions as an anti-mitotic agent. It is a derivative of estradiol with a nitrogen mustard-carbamate ester moiety, giving it alkylating properties. In vivo, it can alkylate DNA and other cellular components, leading to apoptosis. Due to its estrogen component, it can bind more selectively to active estrogen receptors.
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Niculescu-Duvaz, Ion; Cambanis, A.; Tarnauceanu, E. Potential anticancer agents. II. Urethan-type nitrogen mustards of some natural sex hormones Journal of Medicinal Chemistry (1967), 10(2), 172-4.
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Hogberg, Knut B.; Fex, Hans J.; Konyves, Imre; Kneip, Hans O. J. Steroid esters Ger. (1967), DE 1249862 A1 19670914.
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Nishimura, Masakuni; Sekya, Masatoshi; Aoki, Jun; Myazaki, Okifumi Preparation of estramustine phosphate disodium salt Jpn. Kokai Tokkyo Koho (1994), JP 06107678 A 19940419.
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Tew KD.The mechanism of action of estramustine. Semin Oncol. 1983 Sep;10(3 Suppl 3):21-6.
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