29767-20-2 Teniposide AKSci E655
 
 
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  E655    
Teniposide
, 98% (HPLC)
 
4'-Dimethyl-9-(4,6-O-2-thenyid)-epipodophyllotoxin, Tenoposide, VM-26




IDENTITY
CAS Number:29767-20-2
MDL Number:MFCD00866516
MF:C32H32O13S
MW:656.65
EINECS:249-831-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:242-246°C
Optical Rotation:-107°(9:1 chloroform/methanol)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO
Application(s):A derivative of podophyllotoxin that has shown cytostatic effect & inhibition of topoisomerase II
Form:Free Base
Research Area:Cancer

REVIEW

 Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. It inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate. Teniposide acts primarily in the G2 and S phases of the cycle.

REFERENCES
[1]Nemec, Josef Epipodophyllotoxinquinone glucoside derivatives and their use PCT Int. Appl. (1986), WO 8600018 A1 19860103.
[2] Thurston, Lee S.; Imakura, Yasuhiro; Haruna, Mitsumasa; Li, De Hua; Liu, Zong Chao; Liu, Su Ying; Cheng, Yung Chi; Lee, Kuo Hsiung Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and alpha-peltatin Journal of Medicinal Chemistry (1989), 32(3), 604-8.
[3] Lu M; Xu H Recent advances in semisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: an update (2008-2010) Mini reviews in medicinal chemistry (2011), 11(10), 901-9.
[4] Nissen NI, Dombernowsky P, Hansen HH, Pedersen AG.The epipodophyllotoxin derivatives VM-26 and VP-16-213, 1976-1979, a review. Recent Results Cancer Res. 1980;74:98-106.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 12, 2024


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All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Teniposide, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES

 APIs and Bioactives > Chemotherapeutics


PubChem
  @PubMed