29110-48-3 Guanfacine HCl AKSci E635
 
 
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  E635    AKSci Reference Standard
Guanfacine HCl
, 98%
 
N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride
N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride




IDENTITY
CAS Number:29110-48-3
MDL Number:MFCD00798230
MF:C9H10Cl3N3O
MW:282.55
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:213-219°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

BIOLOGICAL INFO
Solubility:H2O: soluble 12mg/mL at 60°C
Application(s):Antihypertensive agent, a-2 noradrenergic receptor agonist
Form:HCl salt

REVIEW

 Guanfacine selectively stimulates central alpha(2)-adrenergic receptors, resulting in inhibition of sympathetic vasomotor centers, which contributes predominantly to the hypotensive effects of the drug. Central effects of guanfacine lead to reduced peripheral sympathetic nerve impulses from the vasomotor center to the heart and blood vessels. This results in a decrease in peripheral vascular resistance and a reduction in heart rate. The stimulation of peripheral alpha(2)-adrenergic receptors may also contribute to hypotensive effects.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 2, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Adrenergic Agonists


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