27848-84-6 Nicergoline AKSci E601
 
 
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  E601    
Nicergoline, 98% (HPLC), powder
 
5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
IDENTITY
CAS Number:27848-84-6
MDL Number:MFCD00869626
MF:C24H26BrN3O3
MW:484.39
EINECS:248-694-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form:White to light yellow powder
Melting Point:135-137°C
Optical Rotation:+5.7°±0.5°, c = 5 in EtOH (95vol%)
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in DMSO (100 mM), alcohol, chloroform, and acetone. Insoluble in water
Application(s):An alpha-adrenergic modulator and vasodilator

REVIEW
 Nicergoline acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergoline is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.

REFERENCES
[1]Winblad B, Fioravanti M, Dolezal T, Logina I, Milanov IG, Popescu DC, Solomon A: Therapeutic use of nicergoline. Clin Drug Investig. 2008;28(9):533-52.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of January 25, 2021


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CATEGORIES
 APIs and Bioactives > Vasodilators


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