25316-40-9 Doxorubicin HCl AKSci E518
 
 
Loading Please Wait...
  E518    
Doxorubicin HCl
, 98% (HPLC)
 
Doxorubicin
DOX, Hydroxydaunorubicin hydrochloride
Adriamycin
more..




IDENTITY
CAS Number:25316-40-9
MDL Number:MFCD00077757
MF:C27H29NO11.HCl
MW:579.98
EINECS:246-818-3
BRN:4229251
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form:Orange to dark orange to light red to dark red to dark red-brown powder
Melting Point:210-220°C
Optical Rotation:+240° to +270° (c=0.1, MeOH)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Inhibits DNA topoisomerase II and induces DNA damage and apoptosis
Form:HCl salt
Research Area:Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.

REVIEW

 A broad spectrum antitumor agent. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Binds covalently to DNA. Inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1. Immunosuppressive. Antineoplastic. Induces apoptosis. Down regulates c-myc and c-jun in doxorubicin-sensitive cells.

REFERENCES
[1]K.B. Wallace. Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis. Cardiovasc. Toxicol. 7, 101 (2007)
[2] Laginha, K.M. Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors. Clinical Cancer Research. October 1, 2005. Vol. 11 (19). Retrieved on April 19, 2007.
[3] Gamo F-J et al. (2010). Thousands of chemical starting points for antimalarial lead identification. Nature 465 (7296): 305-310. PMID 20485427.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H315; H319; H350

Precautionary Statements
P201; P202; P264; P270; P280; P301+P312; P302+P352; P305+P351+P338; P308+P313; P321; P330; P332+P313; P337+P313; P362; P405; P501


Current as of September 17, 2021


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.

WARNING: Attention California residents: This product can expose you to chemicals including Doxorubicin HCl, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Chemotherapeutics


PubChem