23288-49-5 Probucol AKSci E458
 
 
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  E458    AKSci Bulk Reagent
Probucol
, 98% (HPLC)
 



IDENTITY
CAS Number:23288-49-5
MDL Number:MFCD00079281
MF:C31H48O2S2
MW:516.84
EINECS:245-560-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):White to almost white crystalline powder
Melting Point:124-125°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Probucol lowers serum cholesterol by increasing the fractional rate of low-density lipoprotein (LDL) catabolism in the final metabolic pathway for cholesterol elimination from the body. Additionally, probucol may inhibit early stages of cholesterol biosynthesis and slightly inhibit dietary cholesterol absorption. Recent information suggests that probucol may inhibit the oxidation and tissue deposition of LDL cholesterol, thereby inhibiting atherogenesis. It appears to inhibit ABCA1-mediated cellular lipid efflux.

REFERENCES
[1]Neuworth, Martin B. Anticholesteremic 2,2-bis(3,5-dialkyl-4-hydroxyphenylthio)alkanes Fr. (1969), FR 1561853 A 19690328.
[2] Neuworth, Martin B.; Laufer, Rohert J.; Barnhart, James W.; Sefranka, J. A.; McIntosh, D. D. Synthesis and hypocholesterolemic activity of alkylidenedithio bisphenols Journal of Medicinal Chemistry (1970), 13(4), 722-5.
[3] Pfuetze K D; Dujovne C A Probucol Current atherosclerosis reports (2000), 2(1), 47-57.
[4] Favari E, Zanotti I, Zimetti F, Ronda N, Bernini F, Rothblat GHProbucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2345-50. Epub 2004 Oct 28.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of May 22, 2022


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CATEGORIES

 APIs and Bioactives > Hypercholesterolemia


PubChem