22254-24-6, 60205-81-4 Ipratropium bromide AKSci E426
 
 
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  E426    AKSci Reference Standard
Ipratropium bromide
, 98% (HPLC)
 
Atropine isopropyl bromide
Atrovent
Apovent
more..




IDENTITY
CAS Number:22254-24-6, 60205-81-4
MDL Number:MFCD00069291
MF:C20H30BrNO3
MW:412.36
EINECS:244-873-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 83mg/mL; H2O: 10 mg/mL; EtOH: 83mg/mL
Application(s):Bronchodilator Agent; Nonselective muscarinic acetylcholine receptor antagonist
Form:Bromide Salt

REVIEW

 An anticholinergic drug used for the treatment of chronic obstructive pulmonary disease and acute asthma. It blocks the muscarinic acetylcholine receptors in the smooth muscles of the bronchi in the lungs, opening the bronchi.. Ipratropium blocks muscarinic acetylcholine receptors, without specificity for subtypes, and therefore promotes the degradation of cyclic guanosine monophosphate (cGMP), resulting in a decreased intracellular concentration of cGMP.

REFERENCES
[1]Glossop PA, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ (2011). Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease. J Med Chem. 54(19):6888-904. PMID 21870878.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H332; H319

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P304+P340; P305+P351+P338; P312; P330; P337+P313; P501


Current as of October 6, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > AChR Antagonists


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