22254-24-6 Ipratropium bromide AKSci E426
 
 
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  E426    
Ipratropium bromide
, 98% (HPLC)
 
Atropine isopropyl bromide
Atrovent
Apovent
more..




IDENTITY
CAS Number:22254-24-6
MDL Number:MFCD00069291
MF:C20H30BrNO3
MW:412.36
EINECS:244-873-8
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White powder
Long-Term Storage:Store at room temperature
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: 83mg/mL; H2O: 10 mg/mL; EtOH: 83mg/mL
Application(s):Bronchodilator Agent; Nonselective muscarinic acetylcholine receptor antagonist
Form:Bromide Salt

REVIEW

 An anticholinergic drug used for the treatment of chronic obstructive pulmonary disease and acute asthma. It blocks the muscarinic acetylcholine receptors in the smooth muscles of the bronchi in the lungs, opening the bronchi.. Ipratropium blocks muscarinic acetylcholine receptors, without specificity for subtypes, and therefore promotes the degradation of cyclic guanosine monophosphate (cGMP), resulting in a decreased intracellular concentration of cGMP.

REFERENCES
[1]Glossop PA, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ (2011). Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease. J Med Chem. 54(19):6888-904. PMID 21870878.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302+H332; H319

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P304+P340; P305+P351+P338; P312; P330; P337+P313; P501


Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > AChR Antagonists


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