220620-09-7 Tigecycline AKSci E414
 
 
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  E414    
Tigecycline
, 98% (HPLC)
 
9-t-Butylglycylamido-minocycline
Tygacil




IDENTITY
CAS Number:220620-09-7
MDL Number:MFCD00935753
MF:C29H39N5O8
MW:585.65
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:Orange powder
Melting Point:163-173°C
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
UN #:UN3077
Hazard Class:9; Miscellaneous
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

BIOLOGICAL INFO
Solubility:DMSO: =3 mg/mL (warmed)
Application(s):Antibiotic

REVIEW

 Tigecycline, a glycylcycline, inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains. Tigecycline carries a glycylamido moiety attached to the 9-position of minocycline. The substitution pattern is not present in any naturally occurring or semisynthetic tetracycline and imparts certain microbiologic properties to tigecycline. Tigecycline is not affected by the two major tetracycline resistance mechanisms, ribosomal protection and efflux. Accordingly, tigecycline has demonstrated in vitro and in vivo activity against a broad spectrum of bacterial pathogens. There has been no cross resistance observed between tigecycline and other antibiotics. Tigecycline is not affected by resistance mechanisms such as beta-lactamases (including extended spectrum beta-lactamases), target site modifications, macrolide efflux pumps or enzyme target changes (e.g. gyrase/topoisomerase). In vitro studies have not demonstrated antagonism between tigecycline and other commonly used antibacterial drugs. In general, tigecycline is considered bacteriostatic.

REFERENCES
[1]Rose WE, Rybak MJ: Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110.
[2] Kasbekar N: Tigecycline: a new glycylcycline antimicrobial agent. Am J Health Syst Pharm. 2006 Jul 1;63(13):1235-43.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H318; H360; H410

Precautionary Statements
P201; P202; P273; P280; P281; P305+P351+P338; P308+P313; P310; P391; P405; P501


Current as of December 3, 2020


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CATEGORIES

 APIs and Bioactives > Antibacterials, Tetracyclines


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