REVIEW Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.
REFERENCES
[1]
Qweider, M.; Gilsbach, J. M.; Rohde, V. (2007). Inadvertent Intrathecal Vincristine Administration: A Neurosurgical Emergency. Case Report. Journal of Neurosurgery: Spine 6 (3): 280-283. PMID 17355029.
[2]
Graf, W. D.; Chance, P. F.; Lensch, M. W.; Eng, L. J.; Lipe, H. P.; Bird, T. D. (1996). Severe Vincristine Neuropathy in Charcot-Marie-Tooth Disease Type 1A. Cancer 77 (7): 1356-1362. PMID 8608515.
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WARNING: Attention California residents: This product can expose you to chemicals including Vincristine sulfate salt, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to 