[2068-78-2] Vincristine sulfate salt AKSci E375
 
 
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  E375    
Vincristine sulfate salt
, 97% (HPLC)
 



IDENTITY
CAS Number:[2068-78-2]
MDL Number:MFCD08706469
MF:C46H56N4O10.H2SO4
MW:923.36
EINECS:218-190-0
BRN:3924631
SPECIFICATIONS & PROPERTIES
Purity:97% (HPLC)
Available Spectra:FT-IR, LCMS, HPLC
Physical Form:White to off-white to light yellow powder
Melting Point:>300°C
Boiling Point:273-281°C
Long-Term Storage:Store long-term at -20°C
UN #:UN2811
Hazard Class:6.1
Packing Group:II

BIOLOGICAL INFO
Solubility:DMSO: 100mg/mL; H2O: 60mg/mL; EtOH: <1mg/mL; MeOH: 20mg/mL
Application(s):Microtubule function inhibitor
Form:Sulfate salt

REVIEW

 Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.

REFERENCES
[1]Qweider, M.; Gilsbach, J. M.; Rohde, V. (2007). Inadvertent Intrathecal Vincristine Administration: A Neurosurgical Emergency. Case Report. Journal of Neurosurgery: Spine 6 (3): 280-283. PMID 17355029.
[2] Graf, W. D.; Chance, P. F.; Lensch, M. W.; Eng, L. J.; Lipe, H. P.; Bird, T. D. (1996). Severe Vincristine Neuropathy in Charcot-Marie-Tooth Disease Type 1A. Cancer 77 (7): 1356-1362. PMID 8608515.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H300; H341; H361

Precautionary Statements
P201; P202; P264; P270; P281; P301+P310; P308+P313; P321; P330; P405; P501


Current as of October 17, 2017


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CATEGORIES

 APIs and Bioactives > Alkaloids, Chemotherapeutics


PubChem