191114-48-4 Telithromycin AKSci E309
 
 
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  E309    AKSci Reference Standard
Telithromycin
, 95% (HPLC)
 
Ketek




IDENTITY
CAS Number:191114-48-4
MDL Number:MFCD04117983
MF:C43H65N5O10
MW:812.0037
SPECIFICATIONS & PROPERTIES
Purity:95% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:White to off-white to light beige powder
Melting Point:176-188°C
Boiling Point:966°C
Flash Point:>110°C
Long-Term Storage:Store long-term at -20°C
UN #:UN3077
Hazard Class:9
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO, Methanol
Application(s):Antibiotics

REVIEW

 Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.

REFERENCES
[1]Burger, Matthew T.; Bioorganic & Medicinal Chemistry 2006, V14(16), P5592-5604.
[2] Clay KD et al. (2006). Brief communication: severe hepatotoxicity of telithromycin: three case reports and literature review. Annals of Internal Medicine 144 (6): 415-420. PMID 16481451.
[3] Scheinfeld N. Telithromycin: A brief review of a new ketolide antibiotic. J Drug Dermat 2004;3:409-13. PMID 15303785.
[4] D Bertrand, S Bertrand, E Neveu, and P Fernandes (2010). Molecular Characterization of Off-Target Activities of Telithromycin: a Potential Role for Nicotinic Acetylcholine Receptors. Antimicrobial Agents and Chemotherapy. 54: 5399-5402.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 17, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antibacterials, Macrolides


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