18883-66-4 Streptozocin AKSci E301
 
 
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  E301    AKSci Reference Standard
Streptozocin
, 75% alpha-anomer basis
 
Streptozotocin
N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine
Zanosar
more..




IDENTITY
CAS Number:18883-66-4
MDL Number:MFCD00006607
MF:C8H15N3O7
MW:265.22
EINECS:242-646-8
BRN:2060675
SPECIFICATIONS & PROPERTIES
Purity:75% alpha-anomer basis
Spectra:NMR, LCMS, FT-IR, HPLC, Karl-Fischer, ROI
Physical Form:White to off-white to light yellow powder
Melting Point:>121°C (dec.)
Long-Term Storage:Store long-term at -20°C
UN #:UN3077
Hazard Class:9; Miscellaneous
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO: 53mg/mL; H2O: 53mg/mL; EtOH: <1mg/mL
Application(s):Antibiotics; Antineoplastic
Form:Free Base

REVIEW

 Antibiotic and antitumor agent. Streptozotocin is a glucosamine-nitrosourea compound. As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other mechanisms may also contribute. DNA damage induces activation of poly ADP-ribosylation, which is likely more important for diabetes induction than DNA damage itself.

REFERENCES
[1]Zhang Y, Zhang Y, Bone RN, Cui W, Peng JB, Siegal GP, Wang H, Wu H (2012). Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin. PLoS One. 7(5):e36675. PMID 22586489.
[2] Shimoi A, Hatakeyama H, Koizumi H, Satoh H, Watanabe M (2012). Unchanged distribution density of anionic sites on the glomerular wall in rats with streptozotocin-induced diabetic nephropathy. Toxicol Pathol. 40(5):789-96. PMID 22467625.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H350

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of April 8, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.

WARNING: Attention California residents: This product can expose you to chemicals including Streptozocin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Chemotherapeutics


PubChem