REVIEW Antibiotic and antitumor agent. Streptozotocin is a glucosamine-nitrosourea compound. As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other mechanisms may also contribute. DNA damage induces activation of poly ADP-ribosylation, which is likely more important for diabetes induction than DNA damage itself.
Zhang Y, Zhang Y, Bone RN, Cui W, Peng JB, Siegal GP, Wang H, Wu H (2012). Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin. PLoS One. 7(5):e36675. PMID 22586489.
Shimoi A, Hatakeyama H, Koizumi H, Satoh H, Watanabe M (2012). Unchanged distribution density of anionic sites on the glomerular wall in rats with streptozotocin-induced diabetic nephropathy. Toxicol Pathol. 40(5):789-96. PMID 22467625.
For research use only. Not for diagnostic or therapeutic use.
Not for human use.
WARNING: Attention California residents: This product can expose you to chemicals including Streptozocin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.