REVIEW Ornidazole is a nitroimidazole drug used in the treatment of parasitic infections, including amebiasis, giardiasis, and Trichomonas vaginalis; as well as treatment of infections due to susceptible strains of anaerobic bacteria. Once they have entered the cell by diffusion, the antimicrobial toxicity of the nitroimidazoles is dependent on reduction of the nitro moiety to the nitro anion radical and other highly active compounds, including nitroso and hydroxylamine derivatives. These reduction products are damaging to macromolecules, and have been shown to cause DNA degradation and strand breakage which kill the infectious agent or stop it from reproducing. Ornidazole has been investigated for use in Crohn's disease after bowel resection.
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