16773-42-5 Ornidazole AKSci E217
 
 
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  E217    AKSci Bulk Reagent
Ornidazole
, 98% (HPLC)
 
1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole




IDENTITY
CAS Number:16773-42-5
MDL Number:MFCD00057960
MF:C7H10ClN3O3
MW:219.63
EINECS:240-826-0
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:85-90°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Ornidazole is a nitroimidazole drug used in the treatment of parasitic infections, including amebiasis, giardiasis, and Trichomonas vaginalis; as well as treatment of infections due to susceptible strains of anaerobic bacteria. Once they have entered the cell by diffusion, the antimicrobial toxicity of the nitroimidazoles is dependent on reduction of the nitro moiety to the nitro anion radical and other highly active compounds, including nitroso and hydroxylamine derivatives. These reduction products are damaging to macromolecules, and have been shown to cause DNA degradation and strand breakage which kill the infectious agent or stop it from reproducing. Ornidazole has been investigated for use in Crohn's disease after bowel resection.

REFERENCES
[1]Jakubcova, Jozefina; David, Ladislav; Rybar, Alfonz; Frimm, Richard; Martvon, Augustin 1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole Czech. (1984), CS 211414 B1 19820226.
[2] Simko, Marian; Bachraty, Frantisek; Zlatinsky, Emil; David, Ladislav; Rybar, Alfonz Preparation of 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole as an antiprotozoal drug Czech. (1987), CS 237849 B1 19851016.
[3] Massonneau, Viviane; Mulhauser, Michel Process for the preparation of 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitro-imidazole (ornidazole) Eur. Pat. Appl. (1990), EP 399901 A1 19901128.
[4] Singh, Paramjeet; Mittal, Rohit; Sharma, G. C.; Singh, Sukhjeet; Singh, Amarjit Ornidazole: comprehensive profile Profiles of Drug Substances, Excipients, and Related Methodology (2003), 30, 123-184.
[5] Dubreuil, L 5-nitroimidazoles Edited by Bryskier, Andre , Antimicrobial Agents (2005), 930-940.
[6] Lindmark D.G., Muller M.: Antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles. Antimicrob Agents Chemother 1976; 10:476-482.
[7] Soares, Monica Felts de La Roca; Luciano de Gois da Silva, Mima; Sobrinho, Jose Lamartine Soares; Rolim Neto, Pedro Jose Ornidazole: structure and use in the treatment and prophylaxis of bacterial, parasitic and associated Revista Brasileira de Farmacia (2011), 92(4), 253-261.
[8] Rutgeerts P, Van Assche G, Vermeire S, D'Haens G, Baert F, Noman M, Aerden I, De Hertogh G, Geboes K, Hiele M, D'Hoore A, Penninckx F Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2005 Apr;128(4):856-61.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 9, 2024


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CATEGORIES

 APIs and Bioactives > Antiparasitics


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