148849-67-6 Ivabradine HCl AKSci E147
 
 
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  E147    
Ivabradine HCl, 99% (HPLC)
 



IDENTITY
CAS Number:148849-67-6
MDL Number:MFCD00929899
MF:C27H37ClN2O5
MW:505.05
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:135-140°C
Optical Rotation:+5 - +9 °(c=1, DMSO)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 101mg/mL; H2O: >=5mg/mL; EtOH: 101mg/mL
Application(s):Cardiotonic Agent; Pacemaker Current (If) Inhibitor
Form:HCl salt

REVIEW
 Ivabradine is a novel medication used for the symptomatic management of stable angina pectoris. Ivabradine selectively inhibits the pacemaker If current in a dose-dependent manner. Blocking this channel reduces cardiac pacemaker activity, slowing the heart rate and allowing more time for blood to flow to the myocardium.

REFERENCES
[1]Sosunov EA, Anyukhovsky EP (2012). Differential effects of ivabradine and ryanodine on pacemaker activity in canine sinus node and purkinje fibers. J Cardiovasc Electrophysiol. 23(6):650-5. PMID 22353259.
[2] Adile KK, Kapoor A, Jain SK, Gupta A, Kumar S, Tewari S, Garg N, Goel PK (2012). Safety and efficacy of oral ivabradine as a heart rate-reducing agent in patients undergoing CT coronary angiography. Br J Radiol. 85(1016):e424-8. PMID 22815422.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H410

Precautionary Statements
P273; P391; P501

Current as of April 18, 2024


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