155213-67-5 Ritonavir AKSci E144

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E144 AKSci Reference Standard
Ritonavir, >98% (HPLC)

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Norvir

A-84538

ABT-538

IDENTITY
CAS Number:	155213-67-5
MDL Number:	MFCD00927142
MF:	C37H48N6O5S2
MW:	720.94

SPECIFICATIONS & PROPERTIES
Purity:	>98% (HPLC)
Spectra:	FT-IR, LCMS, HPLC, Polarimetry
Physical Form:	White to off-white powder
Melting Point:	126-132°C
Optical Rotation:	+7 ~ +10°(c=2, MeOH)
Long-Term Storage:	Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:	DMSO: 20mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):	HIV protease Inhibitor
Form:	Free Base

REVIEW
An antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS. Ritonavir is a peptidomimetic inhibitor of both the HIV-1 and HIV-2 proteases. Inhibition of HIV protease renders the enzyme incapable of processing the gag-pol polyprotein precursor which leads to production of non-infectious immature HIV particles.

REFERENCES

[1]	Cooper C, la Porte C, Tossonian H, Sampalis J, Ackad N, Conway B (2012). A pilot, prospective, open-label simplification study to evaluate the safety, efficacy, and pharmacokinetics of once-daily lopinavir-ritonavir monotherapy in HIV-HCV coinfected patients: the MONOCO study. HIV Clin Trials. 13(4):179-88. PMID 22849960.
[2]	Morgan RE, Campbell SE, Suehira K, Sponseller CA, Yu CY, Medlock MM (2012). Effects of steady-state lopinavir/ritonavir on the pharmacokinetics of pitavastatin in healthy adult volunteers. J Acquir Immune Defic Syndr. 60(2):158-64. PMID 22627182.

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