155213-67-5 Ritonavir AKSci E144
 
 
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  E144    AKSci Reference Standard
Ritonavir
, >98% (HPLC)
 
Norvir
A-84538
ABT-538




IDENTITY
CAS Number:155213-67-5
MDL Number:MFCD00927142
MF:C37H48N6O5S2
MW:720.94
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:FT-IR, LCMS, HPLC, Polarimetry
Physical Form:White to off-white powder
Melting Point:126-132°C
Optical Rotation:+7 ~ +10°(c=2, MeOH)
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO: 20mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):HIV protease Inhibitor
Form:Free Base

REVIEW

 An antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS. Ritonavir is a peptidomimetic inhibitor of both the HIV-1 and HIV-2 proteases. Inhibition of HIV protease renders the enzyme incapable of processing the gag-pol polyprotein precursor which leads to production of non-infectious immature HIV particles.

REFERENCES
[1]Cooper C, la Porte C, Tossonian H, Sampalis J, Ackad N, Conway B (2012). A pilot, prospective, open-label simplification study to evaluate the safety, efficacy, and pharmacokinetics of once-daily lopinavir-ritonavir monotherapy in HIV-HCV coinfected patients: the MONOCO study. HIV Clin Trials. 13(4):179-88. PMID 22849960.
[2] Morgan RE, Campbell SE, Suehira K, Sponseller CA, Yu CY, Medlock MM (2012). Effects of steady-state lopinavir/ritonavir on the pharmacokinetics of pitavastatin in healthy adult volunteers. J Acquir Immune Defic Syndr. 60(2):158-64. PMID 22627182.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501


Current as of July 4, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antivirals, Antiretrovirals, HIV Protease Inhibitors


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