151767-02-1 Montelukast sodium AKSci E117
 
 
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  E117    AKSci Reference Standard
Montelukast sodium, 98% (HPLC)
 
1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate
IDENTITY
CAS Number:151767-02-1
MDL Number:MFCD00931431
MF:C35H35ClNNaO3S
MW:608.17
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, FT-IR, HPLC
Physical Form:Off-white to light yellow crystalline powder
Melting Point:84-90°C
Optical Rotation:+95.0° - +105.0° (c=1, MeOH)
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO: =8 mg/mL at 60 °C
Application(s):Receptor antagonist (LTRA)

REVIEW
 Montelukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Montelukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of July 12, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Leukotrine Receptor Antagonists


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