REVIEW Indinavir is a HIV-1 protease inhibitor which inhibits the HIV viral protease enzyme, preventing cleavage of the viral gag-pol polyprotein, resulting in the formation of noninfectious, immature viral particles. Indinavir is used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.
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Plosker GL, Noble S. Indinavir: a review of its use in the management of HIV infection. Drugs. (1999), 58(6), 1165-203.
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Pradier C, Pesce A, Carrieri P, Cottalorda J, Boyer P, Senesi C, Fuzibet JG, Dellamonica P, Cassuto JP :Effect of indinavir and higher CD4+ T-cell count on viral load response after 6 months of highly active antiretroviral therapy. Clin Ther. (1999)21(8):1313-20.
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Lacy MK, Abriola KP. Indinavir: a pharmacologic and clinical review of a new HIV protease inhibitor. Conn Med. (1996), 60(12):723-7.
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