150378-17-9 Indinavir AKSci E104
 
 
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  E104    AKSci Reference Standard
Indinavir
, 98% (HPLC), powder
 
2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate hydrate
Crixivan hydrate




IDENTITY
CAS Number:150378-17-9
MDL Number:MFCD00866938
MF:C36H47N5O4
MW:613.79
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:150-159°C
Optical Rotation:+24.1° (c=0.0133, chloroform)
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:Water: 0.015 mg/mg (unbuffered)

REVIEW

 Indinavir is a HIV-1 protease inhibitor which inhibits the HIV viral protease enzyme, preventing cleavage of the viral gag-pol polyprotein, resulting in the formation of noninfectious, immature viral particles. Indinavir is used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and AIDS.

REFERENCES
[1]Boyd M. Indinavir: the forgotten HIV-protease inhibitor. Does it still have a role? Expert Opin Pharmacother (2007)8(7):957-64.
[2] Plosker GL, Noble S. Indinavir: a review of its use in the management of HIV infection. Drugs. (1999), 58(6), 1165-203.
[3] Pradier C, Pesce A, Carrieri P, Cottalorda J, Boyer P, Senesi C, Fuzibet JG, Dellamonica P, Cassuto JP :Effect of indinavir and higher CD4+ T-cell count on viral load response after 6 months of highly active antiretroviral therapy. Clin Ther. (1999)21(8):1313-20.
[4] Lacy MK, Abriola KP. Indinavir: a pharmacologic and clinical review of a new HIV protease inhibitor. Conn Med. (1996), 60(12):723-7.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 13, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antivirals, HIV Protease Inhibitors


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