145202-66-0 Rizatriptan benzoate AKSci E047
 
 
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  E047    
Rizatriptan benzoate
, 98% (HPLC), powder
 
MK-462
Maxalt
N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt




IDENTITY
CAS Number:145202-66-0
MDL Number:MFCD00866224
MF:C22H25N5O2
MW:391.47
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC), powder
Spectra:FT-IR, LCMS, HPLC
Physical Form:White to off-white to beige powder
Melting Point:175-184°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 20mg/mL; H2O: 46mg/mL; EtOH: <1mg/mL
Application(s):5-HT1 agonist
Form:Benzoate salt

REVIEW

 A serotonin 5-HT1 agonist triptan drug for the treatment of migraine headaches.

REFERENCES
[1]Ho TW, Pearlman E, Lewis D, Hämäläinen M, Connor K, Michelson D, Zhang Y, Assaid C, Mozley LH, Strickler N, Bachman R, Mahoney E, Lines C, Hewitt DJ; Rizatriptan Protocol 082 Pediatric Migraine Study Group (2012). Efficacy and tolerability of rizatriptan in pediatric migraineurs: results from a randomized, double-blind, placebo-controlled trial using a novel adaptive enrichment design. Cephalalgia. 32(10):750-65. PMID 22711898.
[2] Müller T, Lohse L (2011). Efficacy of parecoxib, sumatriptan, and rizatriptan in the treatment of acute migraine attacks. Clin Neuropharmacol. 34(6):206-9. PMID 21996647.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of July 2, 2020


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CATEGORIES

 APIs and Bioactives > Serotonin Agonists


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