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REVIEW Octhilinone is a biocide and fungicide used in various formulations, including latex paints. A cysteine-reagent compound, it has been shown to inhibit in the nanomolar range monoacylglycerol lipase (MAGL), the major enzyme responsible for the degradation 2-arachidonoylglycerol (2-AG) levels. 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. During the course of octhilinone use, allergic responses to this biocide have become well-documented, requiring obvious care in the protection of the user.
REFERENCES
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Lewis, Sheldon N.; Miller, George A.; Law, Andrew B. 3-Isothiazolones as biocides U.S. (1978), US 4105431 A 19780808.
[2]
Lein, George Max, Jr. Preparation of isothiazolones as antibacterial agents Eur. Pat. Appl. (1989), EP 318194 A1 19890531.
[3]
Petigara, Ramesh Balubhai; Woodruff, Robert Alva; Pendell, Barry Jack; Leister, Norman Andrew Preparation of salt- and water-free 3-isothiazolones Eur. Pat. Appl. (1991), EP 437354 A1 19910717.
[4]
Morita, Masayuki; Liu, Kokubu; Yoneda, Noriko Method for preparation of 2-alkyl-4-isothiazolin-3-one Jpn. Kokai Tokkyo Koho (2001), JP 2001181266 A 20010703.
[5]
Matuszak N, Es Saadi B, Labar G, Marchand-Brynaert J, Lambert DM. Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7321-4.
[6]
Hansen, Mogens Kragh Allergenic properties of isothiazolinone paint preservatives Faerg och Lack Scandinavia (1987), 33(5), 81-3.
[7]
Seal, Kenneth J. A new generation of isothiazolinone personal care preservatives Speciality Chemicals Magazine (2005), 25(8), 32-33.
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