26530-20-1 Octhilinone AKSci D356
 
 
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  D356    AKSci Bulk Reagent
Octhilinone, 98% (GC)
 
2-Octyl-4-isothiazolin-3-one
2-Octyl-3(2H)-isothiazolone
IDENTITY
CAS Number:26530-20-1
MDL Number:MFCD00072473
MF:C11H19NOS
MW:213.34
EINECS:247-761-7
BRN:1211137
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (GC)
Physical Form (at 20°C):Liquid
Boiling Point:120°C
Density:1.04
Refractive Index:1.5180-1.5220
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2922
Hazard Class:8 (6.1); Corrosive, Poison
Packing Group:II
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

REVIEW
 Octhilinone is a biocide and fungicide used in various formulations, including latex paints. A cysteine-reagent compound, it has been shown to inhibit in the nanomolar range monoacylglycerol lipase (MAGL), the major enzyme responsible for the degradation 2-arachidonoylglycerol (2-AG) levels. 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. During the course of octhilinone use, allergic responses to this biocide have become well-documented, requiring obvious care in the protection of the user.

REFERENCES
[1]Lewis, Sheldon N.; Miller, George A.; Law, Andrew B. 3-Isothiazolones as biocides U.S. (1978), US 4105431 A 19780808.
[2] Lein, George Max, Jr. Preparation of isothiazolones as antibacterial agents Eur. Pat. Appl. (1989), EP 318194 A1 19890531.
[3] Petigara, Ramesh Balubhai; Woodruff, Robert Alva; Pendell, Barry Jack; Leister, Norman Andrew Preparation of salt- and water-free 3-isothiazolones Eur. Pat. Appl. (1991), EP 437354 A1 19910717.
[4] Morita, Masayuki; Liu, Kokubu; Yoneda, Noriko Method for preparation of 2-alkyl-4-isothiazolin-3-one Jpn. Kokai Tokkyo Koho (2001), JP 2001181266 A 20010703.
[5] Matuszak N, Es Saadi B, Labar G, Marchand-Brynaert J, Lambert DM. Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7321-4.
[6] Hansen, Mogens Kragh Allergenic properties of isothiazolinone paint preservatives Faerg och Lack Scandinavia (1987), 33(5), 81-3.
[7] Seal, Kenneth J. A new generation of isothiazolinone personal care preservatives Speciality Chemicals Magazine (2005), 25(8), 32-33.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H311+H331; H314; H317; H410

Precautionary Statements
P261; P264; P270; P271; P272; P273; P280; P301+P330+P331; P303+P361+P353; P304+P340; P305+P351+P338; P310; P322; P333+P313; P361; P363; P391; P403+P233; P405; P501

Current as of April 25, 2024


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Antibacterials, Fungicides
 Specialty Chemicals > Industrial/Commercial Use, Preservatives
 Specialty Chemicals > Industrial/Commercial Use, Preservatives


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