78415-72-2 Milrinone AKSci D270
 
 
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  D270    AKSci Bulk Reagent
Milrinone
, 98% (HPLC)
 
1,6-Dihydro-2-methyl-6-oxo-(3,4''-bipyridine)-5-carbonitrile
Primacor




IDENTITY
CAS Number:78415-72-2
MDL Number:MFCD00133539
MF:C12H9N3O
MW:211.22
EINECS:278-903-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>300°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: >10mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Selective phosphodiesterase 3 inhibitor
Form:Free Base

REVIEW

 Milrinone is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, diabetic neuropathy, and congestive heart failure. It also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.

REFERENCES
[1]Baumann A, Derelle AL, Mertes PM, Audibert G. Seeking new approaches: milrinone in the treatment of cerebral vasospasm. Neurocrit Care. (2012) 16(3): 351-3.
[2] Young, Ronald A.; Ward, Alan. Milrinone. A preliminary review of its pharmacological properties and therapeutic use. Drugs. (1988) 36(2): 158-92.
[3] Colucci W S. Cardiovascular effects of milrinone. American heart journal. (1991) 121(6 Pt 2): 1945-7.
[4] Lesher, George Y.; Gruett, Monte D.Lower-alkyl 2-halo-5-(pyridinyl)nicotinates and their use as cardiotonics U.S. (1981), US 4264612 A 19810428

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301+H311+H331

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P312; P322; P330; P361; P363; P403+P233; P405; P501


Current as of July 12, 2024


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