60719-84-8 Amrinone AKSci D269
 
 
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  D269    
Amrinone, 98% (HPLC)
 
5-Amino-(3,4'-bipyridin)-6(1H)-one
IDENTITY
CAS Number:60719-84-8
MDL Number:MFCD00083228
MF:C10H9N3O
MW:187.2
EINECS:262-390-0
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Application(s):Type 3 pyridine phosphodiesterase inhibitor

REVIEW
 Amrinone is a type 3 pyridine phosphodiesterase inhibitor and positive inotropic cardiotonic with vasodilator properties, and the ability to stimulate calcium ion influx into the cardiac cell. Amrinone is used in the treatment of congestive heart failure. It decreases the pulmonary capillary wedge pressure while increasing cardiac output because it functions as an arterial vasodilator and increases venous capacitance while decreasing venous return. There is a net decrease in myocardial wall tension, and O2 consumption when using amrinone.

REFERENCES
[1]Rao G H; Einzig S; Johnson G J; White J G. Effect of Amrinone, a cardiotonic drug, on hemodynamics and platelet function. Prostaglandins and Medicine. (1981) 6(1): 51-64.
[2] Alousi, Adawia A.; Farah, Alfred E. Amrinone: a new oral and parenteral cardiotonic agent. Trends in Pharmacological Sciences. (1980) 1(6): 143-6.
[3] Ward, A.; Brogden, R. N.; Heel, R. C.; Speight, T. M.; Avery, G. S. Amrinone. A preliminary review of its pharmacological properties and therapeutic use. Drugs. (1983) 26(6): 468-502.
[4] Lesher, George Y.; Opalka, Chester J., Jr.5-(Pyridinyl)-2(1H)-pyridinones U.S. (1978), US 4107315 A 19780815

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of April 24, 2024


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