1937-19-5 Aminoguanidine hydrochloride AKSci D015
 
 
Loading Please Wait...
  D015    AKSci Bulk Reagent
Aminoguanidine hydrochloride, 98%
 
Guanylhydrazine hydrochloride
2-Aminoguanidine hydrochloride
Pimagedine hydrochloride
IDENTITY
CAS Number:1937-19-5
MDL Number:MFCD00039074
MF:CH7ClN4
MW:110.55
EINECS:217-707-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:162-168°C
Flash Point:Not applicable°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: 10mg/mL
Application(s):Diaminase oxidase and inducible nitric oxide synthase

REVIEW
 Aminoguanidine hydrochloride also known Pimagedine has been shown to be an effective agent in reducing the severity of the structural and functional alterations associated with experimental diabetic nephropathy (end stage kidney failure). The compound is an inhibitor of diamine oxidase and inducible nitric oxide synthase (an enzyme that underlies injury associated with intestinal inflammation). It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.

REFERENCES
[1]W Kline Bolton, Emaad Abdel-Rahman (2002). Pimagedine: a novel therapy for diabetic nephropathy. Expert Opinion on Investigational Drugs 11 (4): 565-574.
[2] JA Corbett, RG Tilton, K Chang, KS Hasan, Y Ido, JL Wang, MA Sweetland, JR Jr Lancaster, JR Williamson, ML McDaniel. Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes. 1992; 41(4):552-6.
[3] JA Corbett, ML. McDaniel. Selective inhibition of inducible nitric oxide synthase by aminoguanidine. Methods Enzymol. (1996), 268, 398.
[4] F Laszlo, SM Evans, BJ Whittle. Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur J Pharmacol. 1995; 272(2-3) 169-75

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340+P312; P305+P351+P338; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 25, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives >


PubChem
  @PubMed