63449-41-2 Benzalkonium chloride AKSci C997
 
 
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  C997    
Benzalkonium chloride
 
Alkylbenzyldimethylammonium chloride
Alkyldimethylbenzylammonium chloride




IDENTITY
CAS Number:63449-41-2
MDL Number:MFCD00145757
MF:C6H5CH2N(CH3)2C14H29Cl
MW:367.3
EINECS:264-151-6
BRN:4062599
SPECIFICATIONS & PROPERTIES
Spectra:NMR, FT-IR, LCMS, HPLC
Physical Form:White to light yellow to beige powder or solid
Melting Point:50-55°C
Long-Term Storage:Store at room temperature
UN #:UN3261
Hazard Class:8
Packing Group:II

REVIEW

 The mechanism of bactericidal/microbicidal action of benzalkonium chloride is thought to be due to disruption of intermolecular interactions. This can cause dissociation of the cells' membrane of microorganisms, which induces leakage of cell's contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. Cell enzymes, which finely control a plethora of respiratory and metabolic cellular activities, are particularly susceptible to deactivation.

REFERENCES
[1]Park HJ, Kang HA, Lee JY, Kim HO (2000). Allergic contact dermatitis from benzalkonium chloride in an antifungal solution. Contact Derm. 42 (5): 306-7. PMID 10789868.
[2] Liu H, Routley I, Teichmann KD (2001). Toxic endothelial cell destruction from intraocular benzalkonium chloride. J Cataract Refract Surg 27 (11): 1746-50. doi:10.1016/S0886-3350(01)01067-7. PMID 11709246.
[3] Chiambaretta F, Pouliquen P, Rigal D (1997). [Allergy and preservatives. Apropos of 3 cases of allergy to benzalkonium chloride]. J Fr Ophtalmol (in French) 20 (1): 8-16. PMID 9099278.
[4] Kanerva L, Jolanki R, Estlander T (2000). Occupational allergic contact dermatitis from benzalkonium chloride. Contact Derm. 42 (6): 357-8. PMID 10871106.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H312; H314; H410

Precautionary Statements
P260; P264; P270; P273; P280; P301+P310; P301+P330+P331; P303+P361+P353; P304+P340; P305+P351+P338; P310; P322; P363; P391; P405; P501


Current as of July 18, 2019


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CATEGORIES

 APIs and Bioactives > Antiseptics
 Reagents > Phase Transfer Catalysts
  Specialty Chemicals > Surfactants


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