58-94-6 Chlorothiazide AKSci C826
 
 
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  C826    
Chlorothiazide
, 98%
 
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide




IDENTITY
CAS Number:58-94-6
MDL Number:MFCD00058576
MF:C7H6ClN3O4S2
MW:295.72
EINECS:200-404-9
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder
Melting Point:>300°C
Density:2.047
Refractive Index:1.801
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:50mg/ml in DMF: clear colorless solution
Form:Free Base
Research Area:cardiovascular disease

REVIEW

 As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H317; H334

Precautionary Statements
P261; P272; P280; P285; P302+P352; P304+P341; P321; P333+P313; P342+P311; P363; P501


Current as of May 23, 2019


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CATEGORIES

 APIs and Bioactives > Diuretics


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