56391-57-2 Netilmicin sulfate, 595ug/mg AKSci C727
 
 
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  C727    AKSci Bulk Reagent
Netilmicin sulfate, 595ug/mg
 



IDENTITY
CAS Number:56391-57-2
MDL Number:MFCD01311715
MF:2C21H41N5O7.5H2SO4
MW:1441.55
EINECS:260-147-3
SPECIFICATIONS & PROPERTIES
Physical Form (at 20°C):Solid
Melting Point:190-195°C
Optical Rotation:+88.0 - +96.0° (c=3, H2O)
Long-Term Storage:Store long-term at 2-8°C
Note:LOD < 15%
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O:9.8-10.2mg/mL
Application(s):Antibiotic

REVIEW
 Aminoglycosides like netilmicin irreversibly bind to specific 30S-subunit proteins and 16S rRNA. Specifically netilmicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes, leaving the bacterium unable to synthesize proteins vital to its growth.

REFERENCES
[1]Hemsworth S, Nunn AJ, Selwood K, Osborne C, Jones A, Pizer B: Once-daily netilmicin for neutropenic pyrexia in paediatric oncology. Acta Paediatr. 2005 Mar;94(3):268-74.
[2] Klingenberg C, Smabrekke L, Lier T, Flaegstad T: Validation of a simplified netilmicin dosage regimen in infants. Scand J Infect Dis. 2004;36(6-7):474-9.
[3] Brooks JR, Marlow N, Reeves BC, Millar MR: Use of once-daily netilmicin to treat infants with suspected sepsis in a neonatal intensive care unit. Biol Neonate. 2004;86(3):170-5. Epub 2004 Jun 29.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H312+H332; H360

Precautionary Statements
P201; P202; P261; P271; P280; P302+P352; P304+P340; P308+P313; P322; P363; P405; P501

Current as of April 25, 2024


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Netilmicin sulfate, 595ug/mg, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Antibacterials, Aminoglycosides


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