56390-09-1 Epirubicin HCl AKSci C725
 
 
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  C725    AKSci Reference Standard
Epirubicin HCl, 98% (HPLC)
 
Ellence
Farmorubicin
Pharmorubicin
more..
IDENTITY
CAS Number:56390-09-1
MDL Number:MFCD00941448
MF:C27H29NO11.HCl
MW:579.98
EINECS:260-145-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:185°C
Optical Rotation:274° (c=0.01, in methanol)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 116mg/mL; H2O: 116mg/mL; EtOH: 3mg/mL
Application(s):Antibiotic; DNA tYpoisomerase II Inhibitor; DNA/RNA Synthesis Inhibitor
Form:HCl salt

REVIEW
 Epirubicin is an anthracycline drug used for chemotherapy. Epirubicin acts by intercalating DNA strands. Intercalation results in complex formation which inhibits DNA and RNA synthesis. It also triggers DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death.

REFERENCES
[1]Oberlin O, Rey A, Sanchez de Toledo J, Martelli H, Jenney ME, Scopinaro M, Bergeron C, Merks JH, Bouvet N, Ellershaw C, Kelsey A, Spooner D, Stevens MC (2012). Randomized comparison of intensified six-drug versus standard three-drug chemotherapy for high-risk nonmetastatic rhabdomyosarcoma and other chemotherapy-sensitive childhood soft tissue sarcomas: long-term results from the International Society of Pediatric Oncology MMT95 study. J Clin Oncol. 30(20):2457-65. PMID 22665534.
[2] Tkocz D, Crawford NT, Buckley NE, Berry FB, Kennedy RD, Gorski JJ, Harkin DP, Mullan PB (2012). BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers. Oncogene. 31(32):3667-78. PMID 22120723.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of January 30, 2025

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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