REVIEW Nicardipine hydrochloride is a racemic, dihydropyridine calcium-channel blocker for the treatment of vascular disorders such as chronic stable angina, hypertension, and Raynaud's phenomenon. It inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations.
Iwanami, Masaru; Shibanuma, Tadao; Fujimoto, Masaharu; Kawai, Ryutaro; Tamazawa, Kazuharu; Takenaka, Toichi; Takahashi, Kozo; Murakami, Masuo Synthesis of new water-soluble dihydropyridine vasodilators Chemical & Pharmaceutical Bulletin (1979), 27(6), 1426-40.
Antoncic, Ljubo; Jazbec, Iztok; Kocjan, Darko; Krivec, Ivana Process for the preparation of 2-(benzylmethylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and its hydrochloride salt U.S. (1988), US 4769465 A 19880906.
Sorkin EM, Clissold SP. Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders. Drugs. 1987 Apr;33(4):296-345.