REVIEW An antimetabolite that is used for treatment of cancer. Fluorouracil is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase.
Khan MA, Masood N, Husain N, Ahmad B, Aziz T, Naeem A (2012). A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center. J Pak Med Assoc. 62(5):430-4. PMID 22755303.