50847-11-5 Ibudilast AKSci C511
 
 
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  C511    
Ibudilast
, 98%
 
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine




IDENTITY
CAS Number:50847-11-5
MDL Number:MFCD00864808
MF:C14H18N2O
MW:230.31
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White crystals
Melting Point:53.5-54°C
Density:1.09
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO: 28 mg/mL; H2O: 4.5 mg/mL
Application(s):Phosphodiesterase inhibitor, inhibiting the PDE-4 subtype

REVIEW

 Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day. It has mechanisms that include anti-inflammatory effects, such as phosphodiesterase inhibition, and it also Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

REFERENCES
[1]Kishi, Yukio; Ohta, Seiko; Kasuya, Natsuko; Sakita, Shinya; Ashikaga, Takashi; Isobe, Mitsuaki. Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovascular Drug Reviews. (2001) 19(3): 215-225.
[2] Ledeboer, Annemarie; Hutchinson, Mark R.; Watkins, Linda R.; Johnson, Kirk W. Ibudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion on Investigational Drugs. (2007), 16(7): 935-950.
[3] Rolan, P.; Hutchinson, Mr; Johnson, Kw. Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy. (2009) 10(17): 2897-2904.
[4] Irikura, Tsutomu; Hayashi, Masayuki; Koshirae, Kikuo; Urawa, Hatayama; Hetsugi, Etsuko Blood vessel dilating 3-acyl-2-alkylpyrazolo[1,5-a]pyridines Ger. Offen. (1973), DE 2315801 A1 19731011.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 20, 2019


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