REVIEW Lonidamine is an orally administered small molecule that inhibits glycolysis by the inactivation of hexokinase. This compound has anticancer and antispermatogenic agent in vitro and in vivo. It may increase programmed cell death and trigger apoptosis.
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Di Cosimo, Serena; Ferretti, Gianluigi; Papaldo, Paola; Carlini, Paolo; Fabi, Alessandra; Cognetti, Francesco. Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors. Drugs of Today. (2003) 39(3): 157-173.
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Palazzo, Giuseppe; Silvestrini, Bruno 1-Benzylindazole-3-carboxylic acid derivatives Ger. Offen. (1973), DE 2310031 A1 19730920.
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