104075-48-1 Atipamezole HCl AKSci B818
 
 
Loading Please Wait...
  B818    AKSci Reference Standard
Atipamezole HCl, 98% (HPLC)
 
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride
IDENTITY
CAS Number:104075-48-1
MDL Number:MFCD06407819
MF:C14H17ClN2
MW:248.75
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder or powder
Melting Point:211-225°C
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in water (100 mM) and DMSO (100 mM)
Application(s):A selective alfa2-adrenergic receptor antagonist
Form:HCl salt

REVIEW
 Atipamezole (brand name Antisedan, Pfizer) is a synthetic alpha2-adrenergic antagonist with an imidazole structure, indicated for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been researched in humans as a potential anti-Parkinsonian drug. Receptor binding studies indicate that its affinity for alpha2-adrenoceptors and its alpha2/alpha1 selectivity ratio are considerably higher than those of yohimbine, the prototype alpha2-adrenoceptor antagonist. Atipamezole is not selective for subtypes of alpha2-adrenoceptors. Unlike many other alpha2-adrenoceptor antagonists, it has negligible affinity for 5-HT1A and I2 binding sites.

REFERENCES
[1]Karjalainen, Arto Johannes; Virtanen, Raimo Einari; Karjalainen, Arja Leena; Kurkela, Kauko Oiva Antero Substituted imidazole derivatives and their use Eur. Pat. Appl. (1986), EP 183492 A1 19860604.
[2] Honkavaara, Juhana M.; Raekallio, Marja R.; Kuusela, Erja K.; Hyvarinen, Esko A.; Vainio, Outi M. The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs Veterinary Anaesthesia and Analgesia (2008), 35(5), 409-413.
[3] Talukder, Md. Hasanuzzaman; Hikasa, Yoshiaki; Takahashi, Hajime; Sato, Kanako; Matsuu, Aya Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs. Canadian Journal of Veterinary Research (2009), 73(4), 260-270.
[4] Pertovaara A, Haapalinna A, Sirviö J, Virtanen R. Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11(3):273-88.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 23, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES
 APIs and Bioactives > Alpha Blockers


PubChem
  @PubMed