REVIEW N-tert-Butyl-alpha-phenylnitrone (PBN) is a reactive oxygen species (ROS) scavenger (and spin-trapping agent) to trap free radicals, which cause oxidative damage over the lifetime of the subject, the free radical theory of aging. It is the cumulative and potentially increasing amount of accumulated damage that accounts for the dysfunctions and illnesses seen in normal aging. PBN's effects in animal models are extensive; protection against death after endotoxin shock, protection from ischemia-reperfusion injury, to increasing the life span of mice, protection from bacterial meningitis, thalidomide-induced teratogenicity, drug-induced diabetogenesis, and choline-deficient hepatocarcinogenesis.
J Yang, NH Ahn, M Chang, P Narasimhan, PH Chan, YS Song. Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. J Neurochem. 2013 Feb; 124(4) 523-35.
C Chavarr?a, DI PerezI, C P?rez, JA Morales Garcia, S Alonso-Gil,A P?rez-Castillo, C Gil, JM Souza, W Porcal. Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress. Eur J Med Chem. 2012; 58 44-9.
DZ Lee, JM Chung, K Chung, MG Kang, Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Pain. 2012;153(9):1905-15
DZ Lee, JM Chung, K Chung, MG Kang. Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Biochem Pharmacol. 2012;84(4):486-97