REVIEW N-tert-Butyl-alpha-phenylnitrone (PBN) is a reactive oxygen species (ROS) scavenger (and spin-trapping agent) to trap free radicals, which cause oxidative damage over the lifetime of the subject, the free radical theory of aging. It is the cumulative and potentially increasing amount of accumulated damage that accounts for the dysfunctions and illnesses seen in normal aging. PBN's effects in animal models are extensive; protection against death after endotoxin shock, protection from ischemia-reperfusion injury, to increasing the life span of mice, protection from bacterial meningitis, thalidomide-induced teratogenicity, drug-induced diabetogenesis, and choline-deficient hepatocarcinogenesis.
REFERENCES
[1]
J Yang, NH Ahn, M Chang, P Narasimhan, PH Chan, YS Song. Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. J Neurochem. 2013 Feb; 124(4) 523-35.
[2]
C Chavarr?a, DI PerezI, C P?rez, JA Morales Garcia, S Alonso-Gil,A P?rez-Castillo, C Gil, JM Souza, W Porcal. Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress. Eur J Med Chem. 2012; 58 44-9.
[3]
DZ Lee, JM Chung, K Chung, MG Kang, Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Pain. 2012;153(9):1905-15
[4]
DZ Lee, JM Chung, K Chung, MG Kang. Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Biochem Pharmacol. 2012;84(4):486-97
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
