REVIEW N-tert-Butyl-alpha-phenylnitrone (PBN) is a reactive oxygen species (ROS) scavenger (and spin-trapping agent) to trap free radicals, which cause oxidative damage over the lifetime of the subject, the free radical theory of aging. It is the cumulative and potentially increasing amount of accumulated damage that accounts for the dysfunctions and illnesses seen in normal aging. PBN's effects in animal models are extensive; protection against death after endotoxin shock, protection from ischemia-reperfusion injury, to increasing the life span of mice, protection from bacterial meningitis, thalidomide-induced teratogenicity, drug-induced diabetogenesis, and choline-deficient hepatocarcinogenesis.
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