3376-24-7 N-tert-Butyl-alpha-phenylnitrone AKSci B298
 
 
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  B298    
N-tert-Butyl-alpha-phenylnitrone
, 98%
 
PBN
alpha-Phenyl-N-tert-butylnitrone




IDENTITY
CAS Number:3376-24-7
MDL Number:MFCD00008799
MF:C11H15NO
MW:177.24
EINECS:222-168-6
BRN:2044028
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder or crystals
Melting Point:71-75°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO: soluble

REVIEW

 N-tert-Butyl-alpha-phenylnitrone (PBN) is a reactive oxygen species (ROS) scavenger (and spin-trapping agent) to trap free radicals, which cause oxidative damage over the lifetime of the subject, the free radical theory of aging. It is the cumulative and potentially increasing amount of accumulated damage that accounts for the dysfunctions and illnesses seen in normal aging. PBN's effects in animal models are extensive; protection against death after endotoxin shock, protection from ischemia-reperfusion injury, to increasing the life span of mice, protection from bacterial meningitis, thalidomide-induced teratogenicity, drug-induced diabetogenesis, and choline-deficient hepatocarcinogenesis.

REFERENCES
[1]J Yang, NH Ahn, M Chang, P Narasimhan, PH Chan, YS Song. Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. J Neurochem. 2013 Feb; 124(4) 523-35.
[2] C Chavarr?a, DI PerezI, C P?rez, JA Morales Garcia, S Alonso-Gil,A P?rez-Castillo, C Gil, JM Souza, W Porcal. Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress. Eur J Med Chem. 2012; 58 44-9.
[3] DZ Lee, JM Chung, K Chung, MG Kang, Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Pain. 2012;153(9):1905-15
[4] DZ Lee, JM Chung, K Chung, MG Kang. Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Biochem Pharmacol. 2012;84(4):486-97

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 24, 2019


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