387867-13-2 Tandutinib AKSci A818
 
 
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  A818    
Tandutinib
, 98% (HPLC)
 
MLN518
CT53518




IDENTITY
CAS Number:387867-13-2
MDL Number:MFCD09954147
MF:C31H42N6O4
MW:562.7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:177-178°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):TP-competitive and highly selective inhibitor of Flt3, PDGFR-beta and c-Kit

REVIEW

 Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.

REFERENCES
[1]Brownlow, N., et al. 2008. Leukemia. 22: 1452-1453. PMID: 18185521.
[2] DeAngelo, D.J., et al. 2006. Blood. 108: 3674-3681. PMID: 16902153
[3] Pfister C, et al. Vascular endothelial growth factor signals through platelet-derived growth factor receptor β in meningiomas in vitro. Br J Cancer, 2012, 107(10),1702-13.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 29, 2022


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⚠️
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CATEGORIES

 APIs and Bioactives > Protein Kinase Inhibitors


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