3140-73-6 2-Chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) AKSci A719

Loading Please Wait...

A719
2-Chloro-4,6-dimethoxy-1,3,5-triazine (CDMT), 98% (GC)

IDENTITY
CAS Number:	3140-73-6
MDL Number:	MFCD00075607
MF:	C5H6ClN3O2
MW:	175.57
EINECS:	221-541-0
BRN:	148988

SPECIFICATIONS & PROPERTIES
Purity:	98% (GC)
Physical Form:	White to off-white crystals or powder
Melting Point:	71-80°C
Boiling Point:	99-100°C(1mmHg)
Long-Term Storage:	Store at room temperature

REVIEW
CDMT is a stable, highly reactive peptide coupling agent. It is an useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

REFERENCES

[1]	Tanaka, Tomonari; Organic & Biomolecular Chemistry 2010, V8(22), P5126-5132
[2]	Munetaka Kunishima, Takae Ujigawa, Yoshie Nagaoka, Chiho Kawachi, Kazuhito Hioki, Motoo Shiro. Study on 1,3,5-triazine chemistry in dehydrocondensation: gauche effect on the generation of active triazinylammonium species. Chemistry. 2012 Dec 3;18(49):15856-6.
[3]	Munetaka Kunishima, Masanori Kitamura, Hiroyuki Tanaka, Ichiro Nakakura, Takahiro Moriya, Kazuhito Hioki. Study of 1,3,5-triazine-based catalytic amide-forming reactions: effect of solvents and basicity of reactants. Chem Pharm Bull (Tokyo). 2013;61(8):882-6.
[4]	Jastrzabek K, Bednarek P, Kolesinska B, Kaminski ZJ. Bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether as coupling reagent for peptide synthesis. Chem Biodivers. 2013 May;10(5):952-61.