REVIEW CDMT is a stable, highly reactive peptide coupling agent. It is an useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.
Munetaka Kunishima, Takae Ujigawa, Yoshie Nagaoka, Chiho Kawachi, Kazuhito Hioki, Motoo Shiro. Study on 1,3,5-triazine chemistry in dehydrocondensation: gauche effect on the generation of active triazinylammonium species. Chemistry. 2012 Dec 3;18(49):15856-6.
Munetaka Kunishima, Masanori Kitamura, Hiroyuki Tanaka, Ichiro Nakakura, Takahiro Moriya, Kazuhito Hioki. Study of 1,3,5-triazine-based catalytic amide-forming reactions: effect of solvents and basicity of reactants. Chem Pharm Bull (Tokyo). 2013;61(8):882-6.
Jastrzabek K, Bednarek P, Kolesinska B, Kaminski ZJ. Bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether as coupling reagent for peptide synthesis. Chem Biodivers. 2013 May;10(5):952-61.