3140-73-6 2-Chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) AKSci A719
 
 
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  A719    
2-Chloro-4,6-dimethoxy-1,3,5-triazine (CDMT)
, 98% (GC)
 



IDENTITY
CAS Number:3140-73-6
MDL Number:MFCD00075607
MF:C5H6ClN3O2
MW:175.57
EINECS:221-541-0
BRN:148988
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (GC)
Physical Form:White to off-white crystals or powder
Melting Point:71-80°C
Boiling Point:99-100°C(1mmHg)
Long-Term Storage:Store long-term in a cool, dry place
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

REVIEW

 CDMT is a stable, highly reactive peptide coupling agent. It is an useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

REFERENCES
[1]Tanaka, Tomonari; Organic & Biomolecular Chemistry 2010, V8(22), P5126-5132
[2] Munetaka Kunishima, Takae Ujigawa, Yoshie Nagaoka, Chiho Kawachi, Kazuhito Hioki, Motoo Shiro. Study on 1,3,5-triazine chemistry in dehydrocondensation: gauche effect on the generation of active triazinylammonium species. Chemistry. 2012 Dec 3;18(49):15856-6.
[3] Munetaka Kunishima, Masanori Kitamura, Hiroyuki Tanaka, Ichiro Nakakura, Takahiro Moriya, Kazuhito Hioki. Study of 1,3,5-triazine-based catalytic amide-forming reactions: effect of solvents and basicity of reactants. Chem Pharm Bull (Tokyo). 2013;61(8):882-6.
[4] Jastrzabek K, Bednarek P, Kolesinska B, Kaminski ZJ. Bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether as coupling reagent for peptide synthesis. Chem Biodivers. 2013 May;10(5):952-61.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of December 5, 2020


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CATEGORIES

 Peptide Synthesis >


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