74150-27-9 Pimobendan AKSci A701
 
 
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  A701    AKSci Reference Standard
Pimobendan
, >98% (HPLC)
 
Pimobendane
Pimobendanum
Vetmedin




IDENTITY
CAS Number:74150-27-9
MDL Number:MFCD00761648
MF:C19H18N4O2
MW:334.37
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:240-250°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 67mg/mL; H2O: <1mg/mL; EtOH: 5mg/mL
Application(s):Cardiotonic Agent; Vasodilator Agent; Selective Phosphodiesterase III (PDE3) Inhibitor
Form:Free Base

REVIEW

 Pimobendan is a positive inotrope. It sensitizes and increases the binding efficiency of cardiac myofibril to the calcium ions that are already present without increasing the consumption of oxygen and energy. The drug also causes peripheral vasodilation by inhibiting the function of phosphodiesterase III. This results in decreased pressure, translating into smaller cardiac preload and afterload.

REFERENCES
[1]Gordon SG, Saunders AB, Roland RM, Winter RL, Drourr L, Achen SE, Hariu CD, Fries RC, Boggess MM, Miller MW (2012). Effect of oral administration of pimobendan in cats with heart failure. J Am Vet Med Assoc. 241(1):89-94. PMID 22720992.
[2] Macgregor JM, Rush JE, Laste NJ, Malakoff RL, Cunningham SM, Aronow N, Hall DJ, Williams J, Price LL (2011). Use of pimobendan in 170 cats (2006-2010). J Vet Cardiol. 13(4):251-60. PMID 22030289.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501


Current as of June 25, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Veterinary


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