136310-93-5, 139404-48-1 Tiotropium bromide AKSci A626
 
 
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  A626    
Tiotropium bromide
, 99% (HPLC)
 
Spiriva
Tiova




IDENTITY
CAS Number:136310-93-5, 139404-48-1
MDL Number:MFCD00867027
MF:C19H22BrNO4S2
MW:472.42
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:217-230°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 8mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):AChR; muscarinic receptor antagonist
Form:Bromide

REVIEW

 A muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, on topical application it acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands leading to a reduction in smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect.

REFERENCES
[1]Karner C, Chong J, Poole P (2012). Tiotropium versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 7:CD009285. PMID 22786525.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
None

Hazard Statements
None

Precautionary Statements
Notavailable


Current as of October 2, 2022


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CATEGORIES

 APIs and Bioactives > AChR Antagonists


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