834-28-6 Phenformin hydrochloride AKSci A624
 
 
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  A624    AKSci Reference Standard
Phenformin hydrochloride
, 98% (HPLC)
 
Phenethylbiguanide
Meltrol
Dipar




IDENTITY
CAS Number:834-28-6
MDL Number:MFCD00035039
MF:C10H15N5.HCl
MW:241.72
EINECS:212-637-3
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:FT-IR, LCMS, HPLC
Physical Form:White powder or crystalline powder
Melting Point:173-178°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:H2O: 50mg/ml
Application(s):Biguanide hypoglycemic agent
Form:HCl salt

REVIEW

 Phenformin binds to the AMP-activated protein kinase (AMPK). AMPK is an ultra-sensitive cellular energy sensor that monitors energy consumption and down-regulates ATP-consuming processes when activated. The biguanide phenformin has been shown to independently decrease ion transport processes, influence cellular metabolism and activate AMPK. Phenformin's hypoglycemic activity is related the effect it has in activating AMPK and fooling insulin sensitive cells into thinking that insulin levels are low and causing the body to use glucose as if in a state of low caloric consumption. This drug also seems to inhibit several varients of ATP-sensitive potassium channels (namely the receptor subtype Kir6.1).

REFERENCES
[1]Enia G, Garozzo M, Zoccali C: Lactic acidosis induced by phenformin is still a public health problem in Italy. BMJ. 1997 Nov 29;315(7120):1466-7.
[2] Rosand J, Friedberg JW, Yang JM: Fatal phenformin-associated lactic acidosis. Ann Intern Med. 1997 Jul 15;127(2):170.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of May 23, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Diabetes


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