72559-06-9 Rifabutin AKSci A620
 
 
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  A620    AKSci Reference Standard
Rifabutin
, 98% (HPLC)
 
Ansamycin
Mycobutin
LM 427
more..




IDENTITY
CAS Number:72559-06-9
MDL Number:MFCD00866816
MF:C46H62N4O11
MW:847.0
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:Purple to dark purple powder or crystalline powder
Melting Point:131-141°C (dec.)
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO: 60mg/mL; H2O: <1mg/mL; EtOH: 40mg/mL
Application(s):RNA polymerase inhibitor
Form:Free base

REVIEW

 Rifabutin acts via the inhibition of DNA-dependent RNA polymerase in gram-positive and some gram-negative bacteria, leading to a suppression of RNA synthesis and cell death.

REFERENCES
[1]Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease. Gastroenterology 132 (7): 2313-9. June 2007. doi:10.1053/j.gastro.2007.03.031. PMID 17570206.
[2] Jeong MH, Chung JW, Lee SJ, Ha M, Jeong SH, Na S, Na BS, Park SK, Kim YJ, Kwon KA, Ko KI, Jo Y, Hahm KB, Jung HY (2012). [Comparison of rifabutin- and levofloxacin-based third-line rescue therapies for Helicobacter pylori]. Korean J Gastroenterol. 59(6):401-6. PMID 22735872.
[3] Siegel D, Yan C, Ross D (2012). NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 83(8):1033-40. PMID 22209713.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of May 23, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antibacterials, Rifamycins


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