171596-29-5 Tadalafil AKSci A531
 
 
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  A531    AKSci Reference Standard
Tadalafil
, >99% (HPLC)
 
Cialis
Tadanafil
Adcirca




IDENTITY
CAS Number:171596-29-5
MDL Number:MFCD07771966
MF:C22H19N3O4
MW:389.4
SPECIFICATIONS & PROPERTIES
Purity:>99% (HPLC)
Spectra:LCMS, FT_IR, HPLC
Physical Form:White to off-white powder
Melting Point:296-303°C
Optical Rotation:+71° (c=1, CHCl3)
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Application(s):Phosphodiesterase 5 (PDE5)Inhibitor; Vasodilator Agent
Form:Free base

REVIEW

 Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by tadalafil enhances erectile function by increasing the amount of cGMP.

REFERENCES
[1]Naeije R, Huez S: Expert opinion on available options treating pulmonary arterial hypertension. Expert Opin Pharmacother. 2007 Oct;8(14):2247-65.
[2] Burnett AL: Molecular Pharmacotherapeutic Targeting of PDE5 for Preservation of Penile Health. J Androl. 2007 Oct 17.
[3] Guazzi M, Samaja M: The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development. Curr Med Chem. 2007;14(20):2181-91.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 22, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > PDE5 Inhibitors


PubChem