39809-25-1 Penciclovir AKSci A498
 
 
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  A498    
Penciclovir, 99% (HPLC)
 
2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, BRL-39123
IDENTITY
CAS Number:39809-25-1
MDL Number:MFCD00866931
MF:C10H15N5O3
MW:253.26
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:275-277°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Nucleoside analogue

REVIEW
 Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained in vitro inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. in vitro studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase. The most commonly encountered acyclovir-resistant mutants that are deficient in viral thymidine kinase are also resistant to penciclovir.

REFERENCES
[1]Mode of Antiviral Action of Penciclovir in MRC-5 Cells Infected with Herpes Simplex Virus Type 1 (HSV-1), HSV-2, and Varicella-Zoster Virus David L. Earnshaw, et. al Antimicrob. Agents Chemother. 12th ed., 36, 2747-2757, (1992)

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H319

Precautionary Statements
P264; P280; P305+P351+P338; P337+P313

Current as of October 13, 2024


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CATEGORIES
 APIs and Bioactives > Antivirals


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