39809-25-1 Penciclovir AKSci A498
 
 
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  A498    AKSci Reference Standard
Penciclovir
, 99% (HPLC)
 
2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, BRL-39123




IDENTITY
CAS Number:39809-25-1
MDL Number:MFCD00866931
MF:C10H15N5O3
MW:253.26
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:NMR, LCMS, Ft-IR, HPLC
Physical Form:White or almost white crystalline powder
Melting Point:275-277°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Application(s):Nucleoside analogue

REVIEW

 Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained in vitro inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. in vitro studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase. The most commonly encountered acyclovir-resistant mutants that are deficient in viral thymidine kinase are also resistant to penciclovir.

REFERENCES
[1]Mode of Antiviral Action of Penciclovir in MRC-5 Cells Infected with Herpes Simplex Virus Type 1 (HSV-1), HSV-2, and Varicella-Zoster Virus David L. Earnshaw, et. al Antimicrob. Agents Chemother. 12th ed., 36, 2747-2757, (1992)

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H319

Precautionary Statements
P264; P280; P305+P351+P338; P337+P313


Current as of August 21, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antivirals


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