63449-41-2 Benzalkonium chloride, 50% in Water AKSci 0747AP
 
 
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  0747AP    
Benzalkonium chloride, 50% in Water
 
Structure N/A

IDENTITY
CAS Number:63449-41-2
MDL Number:MFCD00145757
MF:C6H5CH2N(CH3)2C14H29Cl
MW:367.3
EINECS:264-151-6
BRN:4062599
SPECIFICATIONS & PROPERTIES
Physical Form:Liquid
Long-Term Storage:Store long-term at room temperature
UN #:UN1760
Hazard Class:8
Packing Group:III

REVIEW

 The mechanism of bactericidal/microbicidal action of benzalkonium chloride is thought to be due to disruption of intermolecular interactions. This can cause dissociation of the cells' membrane of microorganisms, which induces leakage of cell's contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. Cell enzymes, which finely control a plethora of respiratory and metabolic cellular activities, are particularly susceptible to deactivation.

REFERENCES
[1]Park HJ, Kang HA, Lee JY, Kim HO (2000). Allergic contact dermatitis from benzalkonium chloride in an antifungal solution. Contact Derm. 42 (5): 306-7. PMID 10789868.
[2] Liu H, Routley I, Teichmann KD (2001). Toxic endothelial cell destruction from intraocular benzalkonium chloride. J Cataract Refract Surg 27 (11): 1746-50. doi:10.1016/S0886-3350(01)01067-7. PMID 11709246.
[3] Chiambaretta F, Pouliquen P, Rigal D (1997). [Allergy and preservatives. Apropos of 3 cases of allergy to benzalkonium chloride]. J Fr Ophtalmol (in French) 20 (1): 8-16. PMID 9099278.
[4] Kanerva L, Jolanki R, Estlander T (2000). Occupational allergic contact dermatitis from benzalkonium chloride. Contact Derm. 42 (6): 357-8. PMID 10871106.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H312; H314; H410

Precautionary Statements
P260; P264; P270; P273; P280; P301+P310; P301+P330+P331; P303+P361+P353; P304+P340; P305+P351+P338; P310; P322; P363; P391; P405; P501


Current as of December 11, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antiseptics
 Reagents > Phase Transfer Catalysts
  Specialty Chemicals > Surfactants


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